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Buy Cialis online 10mg, 20mg : No prescription!

Pregnancy and lactation: Not specified

Many drugs can affect the embryo or fetus and even cause the child's birth. In addition, drugs taken by breast milk for the baby and use their influence. Therefore, pregnant women and nursing mothers must be careful not to use drugs.


Adverse effects:

The most common headaches, digestive disorders.

Maybe: back pain, muscle aches, nasal congestion, facial flushing.

Rare: swelling of the eyelids, eye pain, conjunctival congestion, and dizziness.

Almost all the side effects of drugs. This is usually done with the use of multiple doses of drug for a long period of time with respect to various drugs. It is possible, and the characteristics of the particular substance. It can harm the body if the drug causes side effects, discontinue use and consult a doctor.


Terms and Storage: No data

Do not use drugs that are outdated. At best, it will not help in the worst case - cause injuries.

Directions for use:

The erectile dysfunction.

Warning! It should have resulted in the drug using the information in this section. The activity of the drug is very individual, and assign them to the doctor.


Disadvantages of topics:

Concomitant treatment with drugs containing nitrates body, childhood and adolescence in 18 years, hypersensitivity to Cialis 20mg.

Pharmacokinetics

Cialis 20mg is rapidly absorbed orally. C max obtained after about 2 hours, and not dependent on the absorption of food. Cialis 20mg pharmacokinetics in healthy subjects are linear with time and dose. At a dose of 2.5 to 20 mg AUC proportional to dose. Ss plasma levels are reached within 5 days after taking the drug again /

The pharmacokinetics of tadalafil in patients with impaired erectile function is similar to the pharmacokinetics of the drug in patients with erectile dysfunction.

Vd is about 63 l, indicating distribution into the tissues and tadalafil. At therapeutic concentrations, 94% of tadalafil in plasma protein binding. In healthy people less than 0.0005% of the administered dose was found in semen.

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Metabolised by CYP3A4. The major circulating metabolite is metilkateholglyukuronid, which is 13,000 times less potent than tadalafil for PDE5, which makes this maloveryatno metabolite is clinically significant.

In healthy subjects, the mean clearance of tadalafil intake of 2.5 l / ha average T 1/2 - 17.5 hours Tadalafil is excreted predominantly as inactive metabolites, mainly in the faeces in approximately 61%) and to a lesser extent in the urine (approximately 36%).

In patients with mild renal impairment (creatinine clearance 51-80 ml / min) or moderate (creatinine clearance 31-50 ml / min) is greater than the AUC in healthy individuals.
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